Evaluating the Effect of Antiviral Drugs using Polarized Light Imaging and Machine Learning Approaches: The Case of Human-induced Pluripotent Stem Cell-derived Cardiomyocytes
Principal Investigators & Key Members:Stephen Boppart | Marina Marjanovic | Mark Anastasio | Tran Thi Mai | Nguyen Thi Nhung | Wray Buntine | Hieu Pham
In this project, we propose to develop a standard and robust procedure to evaluate the effectiveness of antiviral drugs using label-free, noninvasive light imaging, and machine learning-based approaches. To demonstrate this with a representative example, we will start with the evaluation of the effects of Molnupiravir, used for treating SAR-CoV- 2, on cardiomyocytes derived from a human-induced pluripotent stem cell. This project will then be extended to the evaluation of other antiviral drugs.